Endocrine Abstracts

Introduction: Chronic autoimmune thyroid disease (ATD) or Hashimoto thyroiditis (HT) is one of the main thyroid diseases in pediatric age. HT characterized by the production of anti-thyroid antibodies, by an infiltration of autoreactive B and T lymphocytes into the thyroid parenchyma and by alterations in thyroid function. Coeliac disease (CD) is a systemic autoimmune disease caused by gluten ingestion in genetically predisposed subjects. At presents with a pathognomonic enter...

Background and aims: The ratio of TG/ HDL-C can identify cardiometabolic risk and cardiovascular disease. The visceral adiposity index (VAI) is a sex-specific index, in which measurements of body mass index and waist circumference are combined with TG and HDL-C concentrations. T? study association between VAI and TG/HDL-C and the value of TG/HDL-C ratio as a marker of disfunction of visceral adiposity tissue at patients with acromegaly.Subjects and metho...

Background and aims: The long-acting somatostatin analogs represent are nowadays the first-line medical treatment of acromegaly. To assess the efficacy and tolerability of lanreotide-SR (LSR) in the treatment of active acromegaly.Subjects and methods: Eleven patients (2 men and 9 women; aged 27–75 years, median 47.4 years) were treated in whom active acromegaly with during disease from 1 to 34 years. All patients had the macroadenoma of hypophysis i...

Introduction: Hyperuricemia is increasingly being considered a potential pathogenic factor for T2DM, metabolic syndrome, and several adverse consequences of vascular disease. It has been suggested that xanthine oxidase may underlie the urine acid-T2DM association. The study aimed to determine the associations between clinical parameters, glucose homeostasis, and SXO activity in patients with T2DM.Methods: 125 patients with T2DM, age (58.9±9.4) years...

The aim: To estimate secretory and proliferative activity of pituitary adenoma (isolated somatotropinoma (ST) and somatomammotropinoma (SMT).Subjects and methods: The study included 133 patients (total group: 45 male/88 female), aged 44.0±12.5 year old with acromegaly (95 – with ST and 38 – with SMT). There were estimated patient’s age, age of manifestation of acromegaly (agemanifest.), duration of period before diagnosis (...

Aim: The aim is to study the clinical and hormonal peculiarities of PROL (prolactinoma), manifesting in people under the age of 18 and monitoring the effectiveness of suppressive CAB (Cabergoline, Dostinex) therapy during 12 months period.Materials and methods: The total study included 11 patients with PROL, manifesting in childhood. There were also examined 54 healthy volunteers (25 males and 29 females) aged 15–19 to determine the range of normal ...

Introduction: Cardiovascular complications are the most relevant cause of mortality in patients with acromegaly.Aims: To evaluate the association of diurnal melatonin profile with arterial hypertension in acromegalic patients.Subjects and methods: Thirty seven patients (15 men and 22 women; aged 18–75 years) with acromegaly were under investigation. Blood samples for GH and, IGF1 were taken in fasting state. 6-Sulfatoxymelaton...

Introduction: Cardiovascular complications are the most relevant cause of mortality in patients with acromegaly.Aims: To evaluate the effects of chronic excess of GH, IGF1 and PRL on blood pressure, heart rate and pulse in patients with active acromegaly.Subjects and methods: Sixty-three patients (22 men and 41 women; aged 18–76 years) with macroadenoma of hypophysis (45 – somatotropinoma, 19 – somatomammotropinoma) ...

IntroductionThe practice of screening for many chronic diseases, particularly endocrine pathology, is taking place all over the world. The relevance of screening increases significantly when we are talking about diseases with a torpid manifestation and absence of certain clinical symptoms in the debut. Such diseases include pathological conditions caused by pituitary hormone hypersecretion, in particular, acromegaly.The aim<p c...

IntroductionVitamin D (VitD) is thought to be essential for adequate testosterone (T) secretion in men. In the absence of D-hypovitaminosis, their blood T levels and T to estradiol (E2) ratio values are higher relative to those with VitD deficiency. The correlation between VitD levels and androgenization indices in men of different ages has not been practically studied.The aimTo study blood levels of T and th...